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Peptic ulcer disease (gastric ulcer and duodenal ulcer) is a common clinical problem. The lifetime prevalence of peptic ul-cer disease is 5 % to 10 %. The most important risk factors are infection with H. pylori, NSAID ingestion, and the unopposed hypergastrinemia of Zollinger Ellison syndrome. A number of "myth"factors are clearly not associated with the development of ulcers: stress, personality, occupation, alcohol consump-tion, and diet.