1. Structural damage in the woman's pelvis due to trauma, inflammation, tumors, congenital defects, or degenerative diseases are some major causes of female infertility. These may effect any part of the reproductive anatomy.
2. The most common cause of female infertility is damaged or blocked fallopian tubes. This blocks the meeting of the egg and sperm. Fallopian tube damage is commonly caused by STD's, pelvic surgery, and endometriosis.
3. Endometriosis is believed to release toxic substances that may reduce the potential of the egg being fertilized. It also is said to induce a mild immune response. This could very well mean that the macrophages (immune cells) attack and destroy the eggs or embryos.
4. A damaged ovary (from various causes) that inhibits the release of the egg is also a cause of infertility.
5. Pelvic Inflammatory Disease, Endometriosis, and surgical scarring may also displace an ovary or fallopian tube making it difficult for the fimbriae to perform their job of engulfing the eggs and sending them down the fallopian tubes.
6. Ovulation problems also are a major cause of infertility. Some women do not ovulate, some ovulate too late or too early for conception to occur. Women later in their childbearing years are more likely to have irregular ovulation, and poorer quality eggs. The quality of a woman's eggs is a huge determinant of fertility.
7. Different shapes of the uterus can effect fertility. This may be congenital or caused by certain drugs a mother may have taken during her pregnancy.
8. Damage to the cervix may result in a lack of favorable cervical mucous for the transportation of sperm.
9. Sometimes, women develop antibodies to their partners sperm which elicits and immune or allergic response.

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