An easily overlooked type of abnormality in the colon is the most likely type to turn cancerous, and is more common in this country than previously thought, researchers are reporting.
The findings come from a study of colonos copy, in which a camera-tipped tube is used to examine the lining of the intestine. Generally, doctors search for polyps, abnormal growths that stick out from the lining and can turn into cancer. But another type of growth is much more dangerous, and harder to see because it is flat or depressed and similar in color to healthy tissue.
Japanese researchers became concerned about these flat lesions in the 1980s and '90s, but studies here had mixed results and American doctors tended to think that flat growths were less common and less dangerous in the United States.
The new study, to be published Wednesday in the Journal of the American Medical Association, suggests otherwise.
Some doctors in this country were already alert to flat lesions, but the findings will pose a challenge to others, because it takes a trained and vigilant eye to see the growths and special techniques to remove them. The results also mean it is especially important that patients take the harsh laxatives that many dread in advance of the test. The flat lesions, hard to find even under the best conditions, will be impossible to see if any waste is left in the bowel.
Colon cancer is the second-leading cause of cancer death in the United States, after lung cancer, with about 154,000 new cases detected and 52,000 deaths a year. It is one of the few cancers that is totally preventable if precancerous growths are found and removed; it can also be cured with surgery alone if found early enough.
People who have just had a colonoscopy should not rush to schedule another one just to look for the flat growths, doctors said.
"I don't think people have to panic that they've somehow been neglected and had poor care," said Dr. David A. Rothenberger, deputy chairman of surgery at the University of Minnesota.
