The study was led by Siba Raychaudhuri, a faculty member of the University of California, Davis, in the United States. According to an interview with the journal, Dr. Raychaudhuri said, "The high incidence of adverse affects associated with currently available medications has created great interest in the search for an effective and safe alternative treatment."

Raychaudhuri continued, "AKBA has anti-inflammatory properties, and we have shown that a Boswellia serrata extract with concentrated AKBA can be an effective treatment for osteoarthritis of the knee."

Seventy-five OA patients were included in the study. Divided into three groups of 25, the patients were given daily either 100 mg 5-LOXIN, 250 mg 5-LOXIN or a placebo for 90 days. Each patient was evaluated for pain and physical functions by using the standard tools (VAS - visual analog scale, Lequesne's Functional Index, and Western Ontario and McMaster Universities Osteoarthritis Index) at the baseline (day 0), and at days 7, 30, 60 and 90. Additionally, the cartilage degrading enzyme matrix metalloproteinase-3 was also evaluated in synovial fluid of the knee from OA patients.

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