In a study to be presented Jan. 28 at the 44th annual meeting of the Society of Thoracic Surgeons in Fort Lauderdale, Fla., the Hopkins team found that by combining so-called coronary artery bypass grafting, known as CABG, with surgical ventricular restoration, or SVR, in patients with advanced heart failure, the likelihood of subsequent heart problems was 24 percent, compared to 55 percent in those undergoing CABG alone.
"Cardiologists and cardiac surgeons with patients about to undergo coronary bypass surgery should clearly be considering ventricular restoration," says senior study investigator and cardiac surgeon John Conte, M.D. A quarter-million Americans undergo bypass surgery each year. "For those who qualify for the dual procedure, the trend is clearly toward living longer, with fewer hospitalizations and improved quality of life."
Moreover, Conte says, the combined procedure in patients with moderate heart failure offers increased chance to delay or put off entirely the need for a heart transplant. He points out that there is a tremendous shortage of organs available for heart transplantation, with nearly 3,000 Americans currently on waiting lists.
Conte, an associate professor of surgery at the Johns Hopkins University School of Medicine and its Heart Institute, cautions that not all CABG patients can benefit from SVR and that the procedure is most appropriate for those with moderate to severe heart failure, whose pumping function has dropped to less than 35 percent (with 65 percent being normal), and who have suffered a clearly defined heart attack in the heart's main pumping chamber, the left ventricle. "We estimate that about one in 20 CABG patients who have congestive heart failure are in this category from the volume of patients we see here at Hopkins," says Conte.
The new study compared results for two groups of men and women at Hopkins, with similar degrees of heart failure and medical histories. One group of 62 had the dual procedure and another group of 58 had CABG only. All were operated on between June 2002 and December 2005 and monitored afterwards by phone and regular check-ups.
The study is believed to be the first head-to-head comparison of the single and dual procedures that applied strict scientific controls, using similar patients in both groups and the same team of surgeons to ensure a uniform quality of surgery.
Results showed that heart function improved for 80 percent of patients who had the combination procedure and for 57 percent who had the single procedure. Signs of progress included being able to stay active, take walks and participate in normal, everyday activities, such as getting dressed, without becoming exhausted and short of breath.
Death rates during surgery with either CABG alone or CABG with SVR remained the same (at 5.2 percent and 6.4 percent, respectively) and measures of pumping function, called the ejection fraction, also improved by the same amount (at 32 percent and 34 percent.)
Researchers plan to continue monitoring the study patients to better assess long-term survival rates.
"Surgical ventricular restoration can be performed with minimal training and by any cardiac surgeon," says Conte, who has performed nearly 150 of the dual procedures since 2000.
The add-on procedure, he says, takes a half hour beyond the average two-hour, single CABG surgery, in which arteries from other parts of the body are transplanted to the heart in order to increase its blood supply and to get around, or bypass, arteries narrowed from disease.
